Three novel compounds from the leaves of Smallanthus sonchifolius.
نویسندگان
چکیده
Three novel compounds, together with five known ingredients, octacosanol, 3',4',5-trihydroxy-3,7-dimethoxyflavone, 3,4-dihydroxybenzaldehyde, isorhamnetin, and ent-kaurane-3beta,16beta,17-triol, were obtained from the leaves of Smallanthus sonchifolius (yacon), and their structures were elucidated as ent-kaurane-3beta,16beta,17,18-tertol (1), 3R,7E-9-butoxyl-megastigma-3-ol-3-O-beta-D-glucopyranoside (2), and 3S,5R,6Z-megastigma-6-en-3,5,8,9-tertol (3) on the basis of spectroscopic and chemical methods.
منابع مشابه
Antimicrobial activity of the constituents of Smallanthus sonchifolius leaves against methicillin-resistant Staphylococcus aureus.
BACKGROUND AND OBJECTIVES Methicillin-resistant Staphylococcus aureus (MRSA) has been a serious problem as its infection is associated with higher mortality and increase cost worldwide. In the present study, the antibacterial activity of enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifolius was investigated. MATERIAL AND METHODS Enhydrin, polymatin B, allo-schk...
متن کاملImpact of Ohmic-Assisted Decoction on Bioactive Components Extracted from Yacon (Smallanthus sonchifolius Poepp.) Leaves: Comparison with Conventional Decoction.
Yacon (Smallanthus sonchifolius Poepp.) leaves are a potentially rich source of bioactive compounds, such as phenolic acids and flavonoids. In this study, the effect of the extraction method (ohmic-assisted decoction (OH-DE) and decoction (DE)), yacon cultivar (red and white), and leaf age (young and old) on the quality/quantity of extracted phytochemicals were investigated. Extraction yield, e...
متن کاملPurification and identification of antimicrobial sesquiterpene lactones from yacon (Smallanthus sonchifolius) leaves.
The extraction of yacon [Smallanthus sonchifolius (Poepp. and Endl.) H. Robinson; Asteraceae] leaves and chromatographic separation yielded two new antibacterial melampolide-type sesquiterpene lactones, 8beta-tigloyloxymelampolid-14-oic acid methyl ester and 8beta-methacryloyloxymelampolid-14-oic acid methyl ester, as well as the four known melampolides, sonchifolin, uvedalin, enhydrin and fluc...
متن کاملTrypanocidal Activity of Smallanthus sonchifolius: Identification of Active Sesquiterpene Lactones by Bioassay-Guided Fractionation
In order to find novel plant-derived biologically active compounds against Trypanosoma cruzi, we isolated, from the organic extract of Smallanthus sonchifolius, the sesquiterpene lactones enhydrin (1), uvedalin (2), and polymatin B (3) by bioassay-guided fractionation technique. These compounds showed a significant trypanocidal activity against the epimastigote forms of the parasite with IC50 v...
متن کاملBeneficial Effects of an Hydroethanolic Extract of Smallanthus Sonchifolius Leaves on the Metabolic Changes in Diabetic Rats
In this study the anti-hyperglycemic effect of the hydroethanolic extract of Smallanthus sonchifolius leaves (yacon extract) in streptozotocin-induced type 1 diabetic rats (SZT i.p, 50 mg/kg) was characterized, with emphasis on the metabolic changes found in this experimental model. Diabetic and normal rats received extract (400 mg/kg) or water by the oral route for 30 days. At the end of the t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of Asian natural products research
دوره 10 11-12 شماره
صفحات -
تاریخ انتشار 2008